Dr. Xue Liu

Associate Professor, Shenzhen University
Dr. Xue Liu received her PhD in 2017 at Tsinghua University University, China. After completing postdoctoral studies in the department of Fundamental Microbiology, University of Lausanne in Switzerland, she joined Shenzhen University in 2021. Her research interest focused on development of CRISPR-Cas based high-throughput tools for pathogenic bacteria and bacterial pathogenesis and antibiotic resistance.

Education & Working Experience


  • 2011.9 – 2017.7 Ph.D., Tsinghua University School of Medicine, Beijing, China. Supervisor: Jingren Zhang
  • 2015.9 – 2017.1 Joint-Ph.D. student, University of Groningen, Groningen, the Netherlands. Supervisor: Jan-Willem Veening
  • 2007.9 – 2011.6 B.S., Huazhong University of Science & Technology, Wuhan, China. Thesis mentor: Yun Liu

Working Experience

  • 2021.8-now Associate Professor, School of Basic Medical Sciences, Health Science Center, Shenzhen University, Shenzhen, China
  • 2017.10 –2021.7 Postdoc, Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland. Supervisor: Jan-Willem Veening

Personal grants and fellowships

  • 2015-2016 Tsinghua University-Gates Foundation Grand Challenges Explorations (GCE) Grant Agreement, Grant Number: OPP1021992 ($10,000), title “Identification and Mechanistic Analysis of Novel Antibacterial Compounds”
  • 2015-2016 Scholarship under the State Scholarship Fund of China as a joint PhD Student

Invited lectures

  • 2020.12 Invited oral presentation, the 5th anniversary symposium of the Chinese Society of Biochemistry and Molecular Biology, Shenzhen, China
  • 2019.10 Invited oral presentation at the 2nd Asia pneumonia symposium, Beijing, China 2017.9 Invited lecture at the research centre of biochemistry, BGI, Shenzhen, China
  • 2017.9 Invited lecture at the research centre of biochemistry, BGI, Shenzhen, China
  • 2017.6 Oral presentation at the ASM Microbe 2017, American Society for Microbiology Annual Meeting
  • 2017.6 Presentation at the Department of Microbiology, New York University (Invited by Pro. Jeffery Weiser)

Teaching experience

  • Supervisor of master projects: Master student Aya Iizuka (2020), Olivier Bützberger (2018)
  • Supervisor of visiting PhD student: Maria Heggenhougen (2020);Elisabeth Lambert
  • Teaching Assistant: Séquençage d’un génome-Sequencing of a genome, University of Lausanne, 2018
  • Teaching Assistant: Molecular biology techniques and applications, Tsinghua University, 2013-2014


  1. Liu Xue, Kimmey, J.M., Matarazzo, L., de Bakker, V., Van Maele, L., Sirard, J.-C., Nizet, V., and Veening, J.-W. (2021). Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq. Cell Host & Microbe 29, 107-120.e6. (IF=21.023)

  2. Liu Xue, Gallay, C., Kjos, M., Domenech, A., Slager, J., van Kessel, S.P., Knoops, K., Sorg, R.A., Zhang, J.R., and Veening, J.W. (2017). High-throughput CRISPRi Phenotyping Identifies New Essential Genes in Streptococcus pneumoniae. Molecular systems biology 13, 931. (Cover paper, IF=11.429)

  3. Gallay, C., Sanselicio, S., Anderson, M.E., Soh, Y.M., Liu Xue, Stamsås, G.A., Pelliciari, S., van Raaphorst, R., Dénéréaz, J., Kjos, M., et al. (2021). CcrZ is a pneumococcal spatiotemporal cell cycle regulator that interacts with FtsZ and controls DNA replication by modulating the activity of DnaA. Nat Microbiol 6, 1175–1187. (IF=17.745)

  4. Zhang, B. *, Liu Xue *, Lambert, E. *, Mas, G., Hiller, S., Veening, J.-W., and Perez, C. (2020). Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis. Nat Struct Mol Biol 27, 561–569. (Co-first author, IF=15.369)

  5. Liu Xue, Li, J.W., Feng, Z., Luo, Y., Veening, J.W., and Zhang, J.R. (2017). Transcriptional Repressor PtvR Regulates Phenotypic Tolerance to Vancomycin in Streptococcus pneumoniae. Journal of bacteriology 199. (IF=3.490)

  6. Zhu D*, Wang L*, Shang G*, Liu Xue*, Zhu J*, Lu D, Kan B, Zhang JR, Xiang Y. (2014). Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates. Molecular Cell 55:931-937. (*Co-first author, IF=17.97)

  7. Liu, B.*, Liu Xue*, Zhang, J., & Liu, G. (2017). A Natural Lipotrisaccharide and Its Derivatives Selectively Lyse Streptococcus pneumoniae via Interaction with Cell Membrane. ACS Infectious Diseases. (*Co-first author, IF=5.084)

  8. Huang, X., Wang, J., Li, J., Liu, Y., Liu Xue, Li, Z., Kurniyati, K., Deng, Y., Wang, G., Ralph, J.D., et al. (2020). Prevalence of phase variable epigenetic invertons among host-associated bacteria. Nucleic Acids Res 48, 11468–11485. (IF=16.971)

  9. Pan S*, Liu Xue*, Xie Y, Yi Y, Li C, Yan Y, Liu Y. (2010). Esterification Activity and Conformation Studies of Burkholderia cepacia Lipase in Conventional Organic Solvents, Ionic Liquids and Their Co-solvent Mixture Media. Bioresource Technology 101:9822-9824. (Co-first author, IF=9.642)

  10. Yang, H., Liu Xue, Li, Q., Li, L., Zhang, J.R., and Tang, Y. (2016). Total Synthesis and Preliminary SAR study of (+/-)-merochlorins A and B. Organic & biomolecular chemistry 14, 198-205. (IF=3.876)

  11. He, L., Nair, M.K., Chen, Y., Liu Xue, Zhang, M., Hazlett, K.R., Deng, H., and Zhang, J.R. (2016). The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host. Infection and Immunity 84, 1387-1402. (IF=3.441)

  12. Wen, Z., Sertil, O., Cheng, Y., Zhang, S., Liu Xue, Wang, W.C., and Zhang, J.R. (2015). Sequence elements upstream of the core promoter are necessary for full transcription of the capsule gene operon in Streptococcus pneumoniae strain D39. Infection and Immunity 83, 1957-1972. (IF=3.441)

  13. Song YX, Li QL, Liu Xue, Chen YC, Zhang Y, Sun AJ, Zhang WM, Zhang JR, Ju JH. 2014. Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria. Journal of Natural Products 77:1937-1941. (IF=4.050)